Avian influenza vaccines and therapies for poultry.

摘要: Vaccines have been used in avian influenza (AI) control programs to prevent, manage or eradicate AI from poultry and other birds. The best protection is produced the humoral response against hemagglutinin (HA) protein. A variety of vaccines developed tested under experimental conditions with a few receiving licensure field use following demonstration purity, safety, efficacy potency. Current licensed are predominately inactivated whole vaccines, typically low pathogenicity (LP) virus strains, occasionally high strains. Recently, reverse genetic procedures that allow construction vaccine strains using genetically altered HA gene (changing HP proteolytic cleavage site LP) backbone internal segments for safe, growth production. Other include recombinant fowl poxvirus vector an H5 insert Newcastle disease insert. latter can be mass administered via aerosol application.