Carbamazepine hypersensitivity syndrome presenting as vasculitis of the CNS.

摘要: Carbamazepine is a drug widely used in the treatment of partial and generalised tonic-clonic seizures, trigeminal neuralgia other pain syndromes, affective disorders, paroxysmal symptoms multiple sclerosis. Common side effects are diplopia, dizziness, headache, nausea, rash. Less common include blood dyscrasias, toxic hepatitis, hyponatraemia as consequence inappropriate antidiuretic hormone secretion, orofacial dyskinesias, cardiac arrythmias.1 also known to cause severe systemic hypersensitivity reaction, carbamazepine syndrome (CHS).2 It consists triad fever, lymphadenopathy, rash; so called pseudolymphoma syndrome.2 Other organs often involved, most commonly liver and, more rarely, lungs kidneys.3 There two cases meningitis described complication therapy.4 5 We describe case CHS with typical picture involvement organs, including CNS. We suggest possible pathogenetic mechanism for encephalopathy. A 63 year old woman was started on (2×200 mg), seizure prophylaxis after meningeoma operation. About 3 weeks later she developed flu-like illness. Two days afterwards, rash facial oedema, fever appeared. She admitted hospital where physical examination disclosed diffuse purpuric rash, oedema face tongue, pharyngitis, enlargement …