The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids
作者： Sarah Ducastel , Véronique Touche , Mohamed-Sami Trabelsi , Alexis Boulinguiez , Laura Butruille
DOI: 10.1038/S41598-019-56743-X
关键词: Farnesoid X receptor 、 Nuclear receptor 、 Secretion 、 Internal medicine 、 Glucagon-like peptide-1 、 Bile acid 、 Endocrinology 、 Enteroendocrine cell 、 Incretin 、 Chemistry 、 Receptor
摘要: … Glucagon-Like Peptide-1 (GLP-1) by binding to the SCFA receptors FFAR2 and FFAR3 on enteroendocrine L-cells… nuclear Farnesoid X Receptor (FXR) decreases the L-cell response to …
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