GPR43/FFA2: physiopathological relevance and therapeutic prospects

摘要: Research interest in free fatty acid-binding receptors has been growing during the past decade, with an aim to better understand modulation of host physiology response nutrition. G-protein-coupled receptor 43 (GPR43), also called acid 2 (FFA2/FFAR2), binds short-chain acids (SCFAs) produced by microbial fermentation carbohydrates and shown promising therapeutic potential. This review presents current knowledge regarding pharmacological properties GPR43 addresses its functions selected organs (adipose tissue, intestine immune cells). Furthermore, demonstration involvement several pathological conditions such as obesity, inflammatory disease, cancer suggests new fields related this receptor. Finally, could be a key player gut microbes-host crosstalk, although further research is needed clearly evaluate role management health nutrients or treatments targeting microbiota.