Periodontitis, blood lipids and lipoproteins

作者: Francisco Mesa , Antonio Magán-Fernández , Dragana Nikolic , Rafael Marfil-Alvarez , Luigi Nibali

DOI: 10.2217/CLP.14.8

关键词: Chronic periodontitisPeriodontitisLipoproteinBlood lipidsEndocrinologyDental plaqueImmunologyType 2 Diabetes MellitusPorphyromonas gingivalisLow-density lipoproteinMedicineInternal medicine

摘要: Periodontitis, one of the most common chronic infections in adults, is characterized by accumulation dental plaque and infection Gram-negative pathogenic bacteria, which further lead to destruction periodontal tissues. A relationship between periodontitis abnormalities lipid and/or lipoprotein metabolism not well understood yet. Periodontitis associated with elevated proatherogenic plasma lipids, including small dense LDL, while oxidized LDL may act as an inflammatory stimulant periodontitis. Periodontal pathogens directly modify lipoprotein, protective characteristics HDL, contribute development metabolic syndrome, Type 2 diabetes mellitus coronary atherosclerosis. On other hand, treatment modest HDL-C increases, LDL-C decreases consequently lower cardiometabolic risk. Thus, oral check-ups improved hygiene reduce risk antibodies against pathogens. Identific...

参考文章(152)
S. Pauliina Turunen, Outi Kummu, Kirsi Harila, Marja Veneskoski, Rabah Soliymani, Marc Baumann, Pirkko J. Pussinen, Sohvi Hörkkö, Recognition of Porphyromonas gingivalis gingipain epitopes by natural IgM binding to malondialdehyde modified low-density lipoprotein. PLOS ONE. ,vol. 7, ,(2012) , 10.1371/JOURNAL.PONE.0034910
F. D’Aiuto, L. Nibali, M. Parkar, J. Suvan, M.S. Tonetti, Short-term Effects of Intensive Periodontal Therapy on Serum Inflammatory Markers and Cholesterol Journal of Dental Research. ,vol. 84, pp. 269- 273 ,(2005) , 10.1177/154405910508400312
Luigi Nibali, Francesco D'Aiuto, Gareth Griffiths, Kalpesh Patel, Jean Suvan, Maurizio S. Tonetti, Severe periodontitis is associated with systemic inflammation and a dysmetabolic status: a case–control study Journal of Clinical Periodontology. ,vol. 34, pp. 931- 937 ,(2007) , 10.1111/J.1600-051X.2007.01133.X
K. Suzuki, Y. Sakiyama, M. Usui, T. Obama, R. Kato, H. Itabe, M. Yamamoto, Oxidized low-density lipoprotein increases interleukin-8 production in human gingival epithelial cell line Ca9-22. Journal of Periodontal Research. ,vol. 45, pp. 488- 495 ,(2010) , 10.1111/J.1600-0765.2009.01263.X
Hui Chen, Pei Zheng, Haihua Zhu, Jianhua Zhu, Lili Zhao, Nour Eddine El Mokhtari, Jörg Eberhard, Markus Lins, Søren Jepsen, Platelet-activating factor levels of serum and gingival crevicular fluid in nonsmoking patients with periodontitis and/or coronary heart disease. Clinical Oral Investigations. ,vol. 14, pp. 629- 636 ,(2010) , 10.1007/S00784-009-0346-5
Oleh Andrukhov, Hady Haririan, Kristina Bertl, Wolf-Dieter Rausch, Hans-Peter Bantleon, Andreas Moritz, Xiaohui Rausch-Fan, Nitric oxide production, systemic inflammation and lipid metabolism in periodontitis patients: possible gender aspect Journal of Clinical Periodontology. ,vol. 40, pp. 916- 923 ,(2013) , 10.1111/JCPE.12145
H. Robert Superko, Kaspar K. Berneis, Paul T. Williams, Manfredi Rizzo, Peter D. Wood, Gemfibrozil reduces small low-density lipoprotein more in normolipemic subjects classified as low-density lipoprotein pattern B compared with pattern A. American Journal of Cardiology. ,vol. 96, pp. 1266- 1272 ,(2005) , 10.1016/J.AMJCARD.2005.06.069
Mine Kiran, Nejat Arpak, Elif Unsal, Murat Faik Erdogan, The effect of improved periodontal health on metabolic control in type 2 diabetes mellitus. Journal of Clinical Periodontology. ,vol. 32, pp. 266- 272 ,(2005) , 10.1111/J.1600-051X.2005.00658.X
Maurizio S. Tonetti, Francesco D'Aiuto, Luigi Nibali, Ann Donald, Clare Storry, Mohamed Parkar, Jean Suvan, Aroon D. Hingorani, Patrick Vallance, John Deanfield, Treatment of Periodontitis and Endothelial Function The New England Journal of Medicine. ,vol. 356, pp. 911- 920 ,(2007) , 10.1056/NEJMOA063186