Torsade de pointes in a patient with complex medical and psychiatric conditions receiving low-dose quetiapine.
作者： W. V. R. Vieweg , R. K. Schneider , M. A. Wood
DOI: 10.1111/J.1600-0447.2005.00592.X
关键词: Psychiatry 、 Antipsychotic 、 Quetiapine Fumarate 、 QT interval 、 Heart disease 、 Ventricular fibrillation 、 Atypical antipsychotic 、 Torsades de pointes 、 Quetiapine 、 Medicine
摘要: Objective: Describe potential cardiac complications of low-dose quetiapine and other atypical antipsychotic drugs. Method: We present a case report 45-year-old Black woman with multiple medical psychiatric problems taking quetiapine. Results: Coincident generalized seizure, the patient developed ‘ventricular fibrillation’. She was countershocked restoration normal sinus rhythm. The initial electrocardiogram showed QT interval prolongation. Shortly thereafter, classical torsade de pointes appeared, lasted 10 min, resolved spontaneously. Hypomagnesemia present. A electrophysiologist concerned that very slow shortening prolonged QTc after magnesium replacement implicated as risk factor for prolongation pointes. psychosomatic medicine consultant asserted fragmented care almost certainly contributed to patient's problems. discuss cases by newer drugs previous reports our group concerning association psychotropic drugs, prolongation, pointes. Conclusion: Atypical drug administration, when accompanied factors, may contribute arrhythmias including
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