QTc prolongation, torsades de pointes, and psychotropic medications.

摘要: Background Prolongation of the corrected QT (QTc) interval is a key issue for patients who receive psychotropic medications. Such may have baseline clinical risk factors QTc prolongation, and many medications further prolong this interval. This has great relevance, as prolongation linked with dangerous arrhythmias, especially torsades de pointes (TdP). Methods We summarize current literature regarding appropriate methods calculating interval, association TdP, prolongation. then review connections between psychiatric specific focus on antidepressants antipsychotics. Results an established, though imperfect, marker TdP. There are no well-controlled studies that assess TdP associated agents. limited data selective serotonin reuptake inhibitors (SSRIs) class to prolongation; citalopram appears more likely than others induce phenomenon. Among antipsychotics, thioridazine remains agent most intravenous haloperidol also carry increased risk. Of atypical ziprasidone Conclusions The majority in need display few should be considered at low frequency cardiac monitoring receiving individually determined, based prescribed agent(s) additional