Danger-associated molecular patterns (DAMPs) in acute lung injury
作者： Leslie B Tolle , Theodore J Standiford
DOI: 10.1002/PATH.4124
关键词: Immunology 、 ARDS 、 Receptor 、 Chemokine 、 Signal transduction 、 Respiratory disease 、 Lung injury 、 Pattern recognition receptor 、 Fibrosis 、 Medicine
摘要: Danger-associated molecular patterns (DAMPs) are host-derived molecules that can function to regulate the activation of pathogen recognition receptors (PRRs). These play a critical role in modulating lung injury response. DAMPs originate from multiple sources, including injured and dying cells, extracellular matrix, or exist as immunomodulatory proteins within airspace interstitium. either toll-like receptor (TLR) agonists antagonists, modulate both TLR nod-like (NLR) signalling cascades. Collectively, this diverse group may represent important therapeutic targets prevention and/or treatment acute (ALI) its more severe form, respiratory distress syndrome (ARDS).
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