Receptor-Mediated Monitoring of Tissue Well-Being Via Detection of Soluble Heparan Sulfate by Toll-Like Receptor 4

摘要: Perturbations to the well-being of tissues in plants and invertebrates generate fragments endogenous molecules that are recognized by innate immune receptors. Vertebrates have homologous receptors on specialized cells such as dendritic cells, but whether these respond is not known. We tested idea Toll-like might recognize polysaccharide heparan sulfate proteoglycan. Dendritic were found mature response measured costimulatory protein expression, morphology, T lymphocyte stimulation, this maturation was absent when receptor 4 mutated or inhibited. These findings suggest vertebrates may monitor tissue recognizing macromolecules.