Heat Shock Proteins in Immunity

摘要: This chapter focuses on immunological effects of eukaryotic and microbial heat shock proteins (HSPs), with molecular weights about 60, 70, 90 kDa. The search for tumor-specific antigens resulted in the identification HSPs. They have been found to elicit a potent anti-cancer immune response mediated by adoptive innate system. Following receptor-mediated uptake HSP (HSP70 gp96) peptide complexes antigen-presenting cells representation HSP-chaperoned peptides MHC class I molecules, CD8-specific T cell is induced. Apart from chaperoning immunogenic derived tumors, bacterial virally infected cells, they themselves provide activatory signals natural killer (NK) cells. After binding peptide-free HSP70 Toll-like receptors, secretion pro-inflammatory cytokines initiated thus results nonspecific stimulation Moreover, soluble as well membrane-bound tumor can directly activate cytolytic migratory capacity NK form cancer, HSPs different origins, weight kDa, also play pivotal role viral infections, including human simian immunodeficiency virus (HIV, SIV), measles, choriomeningitis. induce tolerance against autoimmune diseases. In summary, depending their mode induction, intracellular/extracellular location, cellular origin (eukaryote/prokaryote), loading status, intracellular ADP/ATP content, concentration, route application, either exert activation danger cancer immunity mediate protection infectious diseases or exhibit regulatory activities controlling preventing autoimmunity.