Implications of Heat Shock Proteins in Carcinogenesis and Cancer Progression
作者： Daniel R. Ciocca , Mariel A. Fanelli , F. Dario Cuello-Carrión , Stuart K. Calderwood
DOI: 10.1007/978-1-4020-6401-2_2
关键词:
摘要: Heat shock proteins (Hsp) participate in many events related to cancer as molecular chaperones, starting from the very beginning of carcinogenesis. Several etiological factors involve Hsp family their mechanisms action, including oncogenic viruses, hereditary and non alterations tumor suppressors or oncoproteins, hypermethylation, radiation carcinogenic agents. All them produce changes response with consequences cell proliferation, differentiation, inflammation, apoptosis, DNA repair, angiogenesis, metastasis, drug resistance immunological mounted by host. In this chapter we will examine participation transformation, either up-regulation down-regulation specific Hsp. This can explain variations expression found pre-neoplastic neoplastic human tumors different tissues organs. These have important clinical progression, exploitation such knowledge may improve anticancer treatment strategies
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