Heat-shock protein expression in leukemia
作者： Lucie Sedlackova , Martin Spacek , Ernst Holler , Zuzana Imryskova , Ilona Hromadnikova
DOI: 10.1007/S13277-010-0088-7
关键词:
摘要: Heat-shock proteins (Hsps) are thought to play a role in the development of cancer and modulate tumor response cytotoxic therapy. In this study, Hsp27, Hsp60, Hsp90α, HspBP1 gene expression was investigated human leukemia cell lines as well cells derived from patients with onset disease. Hsp70 membrane Hsp70, genes were also tested samples patients. Relative Hsps examined patients, using real-time quantitative reverse-transcriptase polymerase chain reaction (RT-PCR). surface studied flow cytometry. All showed significantly increased compared cohort healthy controls; additionally there Hsp27 except for Jurkat CCRF cells. Significantly higher observed peripheral blood bone marrow control samples, while without any significant difference among cohorts. found on defrosted cultured but not unprocessed biological Leukemia heterogeneous pattern Hsp
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