Carrier systems comprising vitamin b12 - biodegradable micro particulate conju gates for peroral delivery of drugs, peptides/proteins and vaccines

作者: Kishore Babu Chalasani , Kondapuram Vijaya Raghavan , Sanjain Kumar Jain , Kollipara Koteshawa Rao , Prakash Vamanrao Diwan

DOI:

关键词: Materials scienceSh groupsDerivatizationCombinatorial chemistryTherapeutic proteinCarrier systemStereochemistryVitamin B12

摘要: The invention relates to a novel complex for oral delivery of drugs, therapeutic protein / peptides and vaccines which are loaded in Vitamin B12 (VB12) coupled particulate carrier system with spacers between, the having formula VB12 - R'/R'-N wherein, R' or is spacer and/or agents derivatization provide either NH2 COOH SH groups, N micro nano particle carriers injectable protein/peptides vaccines.

参考文章(5)
Bernard Vincent Mcinerney, Steven William Westwood, Alison Ruth Gould, Gregory John Russell-Jones, Amplification of the vitamin b12 uptake system using polymers ,(1994)
Steven William Westwood, Gregory John Russell-Jones, Vitamin B12 conjugates with EPO, analogues thereof and pharmaceutical compositions ,(1993)
Steven William Westwood, Gregory John Russell-Jones, Oral delivery systems for microparticles ,(1992)
John F. McEwan, Gregory J. Russell-Jones, Vitamin B12 derivatives and methods for their preparation ,(1999)
Olaf Boris Kinstler, Colin Geoffrey Pitt, Alan David Habberfield, Conjugates of vitamin b12 and proteins ,(1995)