Grafting polyacrylates from carbohydrates by ATRP and formation of nanoparticles for advanced drug delivery

摘要: The present thesis describes synthesis and characterization of graft copolymers from carbohydrates formulation nanoparticles(NP)s for drug carrier application. Side chains were produced grafting carbohydrate based macroinitiators via Atom Transfer Radical Polymerization (ATRP). Firstly, hydrophobic homo-, randomand block-copolymer side grafted a beta-Cyclodextrin core, followed by starch as core. Monomer conversions up to 80% achieved in most cases well controlled polymers obtained. Ni(II) triphenylphosphine complexes found be catalysts superior the known Cu(I) complexes, because they can removed much easier product after polymerization. NPs prepared emulsion-diffusion technique showed particle sizes <200 nm, uniform shape narrow size distribution (PDI<0.1). Not only production parameter but also chemical properties polymer influence stability NPs. Especially hydrophobicity composition arm (block or random) have big on PDI Since cell viabilities remain unaffected these NPs, are good candidates delivery drugs. In conclusion, hydrophobically modified derivatives potential serve new platform biodegradable biocompatible nano carriers.