Highly dense beaded sorbents suitable for fluidized bed applications

摘要: New highly dense beaded sorbents suitable for fluidized bed applications of protein separations are presented. They prepared using porous mineral oxides supporting functional hydrogels responsible interaction. Beads small diameter (70µm) selected to reduce mass transfer resistance. Zirconium oxide was the preferred material due its high density (5.9g/ml) allowing fluidizing liquid velocities (600 cm/h) into columns with a moderate expansion (lower than 3). Composite - hydrogel evaluated their ability rapidly adsorb proteins in and separate an appropriate resolution macromolecule mixtures packed bed. Lysozyme dynamic capacities 68 53 mg per ml sedimented were obtained at 450 900 cm/h.