Site-specific serine phosphorylation of the IL-3 receptor is required for hemopoietic cell survival.
作者： Mark A. Guthridge , Frank C. Stomski , Emma F. Barry , Wendy Winnall , Joanna M. Woodcock
DOI: 10.1016/S1097-2765(05)00002-X
关键词: Transduction (genetics) 、 Biology 、 Cell biology 、 Receptor 、 Cell surface receptor 、 Phosphorylation 、 Colony-stimulating factor 、 Serine 、 Epidermal growth factor 、 Signal transduction
摘要: Abstract In the hemopoietic compartment, IL-3, GM-CSF, and IL-5 receptors are major transducers of survival signals; however, receptor-proximal events that determine this vital function have not been defined. We found IL-3 stimulation induces phosphorylation Ser-585 β c . This promotes association phospho-Ser-585 with 14-3-3 p85 subunit PI 3-K. Mutation specifically impairs 3-K signaling pathway reduces cell in response to IL-3. These results define a distinct receptor–mediated regulated by site-specific receptor serine binding suggest novel mode may be utilized disparate transmembrane as common theme transduction signals.
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