Biochemical assessment of bone loss in patients on long-term thyroid hormone treatment.
作者： J.J. Štěpán , Z. Límanová
DOI: 10.1016/0169-6009(92)90787-E
关键词: Bone remodeling 、 Thyroid Hormone Treatment 、 Osteocalcin 、 Bone resorption 、 Thyroidectomy 、 Hormone 、 Osteopenia 、 Endocrinology 、 Thyroid 、 Internal medicine 、 Medicine
摘要: Summary To test conditions under which thyroid hormone might be deleterious to bone, we studied a group of 58 patients who had undergone thyroidectomy because cancer 1 21 years previously and were treated with steady doses exogenous hormone. Vertebral bone density (BMD Z-score) was significantly reduced biochemical indices resorption (urinary hydroxyproline plasma tartrate-resistant acid phosphatase activity) osteoblastic activity (plasma osteocalcin isoenzyme serum alkaline phosphatase) as well the calculated prevalence relative (HBP) increased in hormone-treated post-menopausal women but not men premenopausal women. The HBP remodeling negatively correlated TSH levels. In patients, BMD Z-score dependent on HBP, menopausal state, duration treatment conclusion, further increase by is predisposed changes turnover. simultaneous evaluation formation improves assessment loss suppressive dose.
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