The effects of thyrotropin-suppressive therapy on bone metabolism in patients with well-differentiated thyroid carcinoma.
作者： K.A. Heemstra , N.A.T. Hamdy , J.A. Romijn , J.W.A. Smit
关键词:
摘要: Patients with differentiated thyroid carcinoma (DTC) are commonly treated long-term thyrotropin (TSH)- suppressive thyroxine replacement therapy resolving in a state of subclinical hyperthyroidism. The relationship between hyperthyroidism and osteoporosis is not clear. In this review, we systematically selected analyzed 21 studies addressing issue. Although multiple methodological differences prevented structured meta-analysis, our data suggest that postmenopausal women most at risk, whereas no increased risk was observed men premenopausal women. Based on these findings believe measurement bone mineral density recommended DTC starting TSH therapy. This should be subsequently regularly measured to enable timely intervention protective agents.
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I Karner, K H Usadel, S Sijanović, Z Hrgović, W J Fassbender, A Klobucar, D Buković, Bone mineral density changes and bone turnover in thyroid carcinoma patients treated with supraphysiologic doses of thyroxine. European Journal of Medical Research. ,vol. 10, pp. 480- 488 ,(2005)
Cheng-Hsiung Chen, Jung-Fu Chen, Bor Yan Yang, Rue-Tsuan Liu, Shih-Chen Tung, Wen-Yen Chien, Yung-Chuan Lu, Ming-Chun Kuo, Ching-Jung Hsieh, Pei-Wen Wang, None, Bone mineral density in women receiving thyroxine suppressive therapy for differentiated thyroid carcinoma Journal of the Formosan Medical Association. ,vol. 103, pp. 442- 447 ,(2004)
Karner I, Sijanovic S, Bone loss in premenopausal women on long-term suppressive therapy with thyroid hormone. Medscape women's health. ,vol. 6, pp. 3- ,(2001)
E. M. Ayling, J. G. Turner, J. R. Elliot, B. E. W. Brownlie, C. M. Florkowski, Bone mineral density in patients receiving suppressive doses of thyroxine for thyroid carcinoma. The New Zealand Medical Journal. ,vol. 106, pp. 443- 444 ,(1993)
Dirk M. Anderson, Eugene Maraskovsky, William L. Billingsley, William C. Dougall, Mark E. Tometsko, Eileen R. Roux, Mark C. Teepe, Robert F. DuBose, David Cosman, Laurent Galibert, A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function Nature. ,vol. 390, pp. 175- 179 ,(1997) , 10.1038/36593
Young-Yun Kong, Ulrich Feige, Iidiko Sarosi, Brad Bolon, Anna Tafuri, Sean Morony, Casey Capparelli, Ji Li, Robin Elliott, Susan McCabe, Thomas Wong, Giuseppe Campagnuolo, Erika Moran, Earl R. Bogoch, Gwyneth Van, Linh T. Nguyen, Pamela S. Ohashi, David L. Lacey, Eleanor Fish, William J. Boyle, Josef M. Penninger, Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand Nature. ,vol. 402, pp. 304- 309 ,(1999) , 10.1038/46303
J.J. Štěpán, Z. Límanová, Biochemical assessment of bone loss in patients on long-term thyroid hormone treatment. Bone and Mineral. ,vol. 17, pp. 377- 388 ,(1992) , 10.1016/0169-6009(92)90787-E
E. Jódar, G. Martínez-Díaz-Guerra, S. Azriel, F. Hawkins, Bone mineral density in male patients with L-thyroxine suppressive therapy and Graves disease. Calcified Tissue International. ,vol. 69, pp. 84- 87 ,(2001) , 10.1007/S002230020041
PIERRE LECOMTE, NICOLE LECUREUIL, CARLOS OSORIO-SALAZAR, MICHEL LECUREUIL, CHANTAL VALAT, Effects of suppressive doses of levothyroxine treatment on sex-hormone-binding globulin and bone metabolism. Thyroid. ,vol. 5, pp. 19- 23 ,(1995) , 10.1089/THY.1995.5.19
J. Lehmke, U. Bogner, D. Felsenberg, H. Peters, H. Schleusener, Determination of bone mineral density by quantitative computed tomography and single photon absorptiometry in subclinical hyperthyroidism: a risk of early osteopaenia in post-menopausal women. Clinical Endocrinology. ,vol. 36, pp. 511- 517 ,(1992) , 10.1111/J.1365-2265.1992.TB02254.X