Actualités dans la prise en charge des cancers thyroïdiens de souche vésiculaire

作者: J. Abeillon-du Payrat , P. Caron , F. Borson-Chazot

DOI: 10.1016/S0003-4266(14)70022-8

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摘要: Resume Les nouvelles recommandations 2014 de l’A merican Thyroid Association sur la prise en charge des cancers thyroidiens souche vesiculaire ont ete presentees au congres Endocrine/ICE a Chicago. Ces vont dans le sens d’une appreciation plus fine du risque individuel et l’adaptation strategies therapeutiques, but ne pas surtraiter faible d’excellent pronostic. Elles proposent une mise jour classification pronostique selon les caracteristiques initiales, precisant lie aux atteintes ganglionnaires, degre d’invasion folliculaires l’apport l’analyse moleculaire. indications, doses modalites preparation traitement par l’iode radioactif (IRA) egalement reevaluees, desescalade therapeutique pour formes recidive. Enfin reponse initial est compte afin d’adapter surveillance objectifs frenateur, qui doivent tenir freination elle-meme. Concernant avancees, pronostic essentiellement sensibilite radioactif. Le systemique refractaires montre resultats prometteurs therapies ciblees, cependant aucune ce n’a demontre d’efficacite termes survie globale, leur utilisation grevee d’effets secondaires souvent invalidants. L’equipe Fagin presente efficacite l’utilisation courte duree d’inhibiteurs selectifs voie MAPK, modeles murins puis chez l’homme, restauration

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