Comparison between colposcopic, cytologic, and histologic findings in women positive and negative for human papillomavirus DNA

作者: Anna-Barbara Moscicki , Jeanette Broering , Kimberly Powell , Judith Klein , Lisa Clayton

DOI: 10.1016/1054-139X(93)90088-7

关键词: Risk factorGynecologyCytologyHuman papillomavirus DNACervixHuman papillomavirusViral diseaseColposcopyVaginal smearMedicine

摘要: Abstract Little is known about the role of detection human papillomavirus (HPV) DNA in exfoliated cells cervix aiding colposcopic diagnosis cervical lesions. The purpose our study was to compare findings young women who were positive and negative for HPV DNA. Eighty-four aged 13–22 years attending family planning clinics examined colposcopically with aide acetic acid Lugol's solution without knowledge status. Lesions identified given scores based on severity observed changes. Samples cytology testing, which included types 6, 11, 16, 18, 31, 33, 35, obtained at time examination. Biopsies performed significant lesions examination or suggestive neoplasia. Students t -test χ 2 analysis variables type. Of 84 examined, 17 DNA; 9 had type 1618. average length sexual activity 2.7 years. Women 1618 a mean 1.7 visible colposcopy compared 0.7 those (this 6,11, 35) ( p

参考文章(18)
Richard Reid, C.Robert Stanhope, Barry R. Herschman, Christopher P. Crum, Samuel J. Agronow, Genital warts and cervical cancer American Journal of Obstetrics and Gynecology. ,vol. 149, pp. 815- 823 ,(1984) , 10.1016/0002-9378(84)90597-0
K. Münger, B.A. Werness, N. Dyson, W.C. Phelps, E. Harlow, P.M. Howley, Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. The EMBO Journal. ,vol. 8, pp. 4099- 4105 ,(1989) , 10.1002/J.1460-2075.1989.TB08594.X
Richard Amsel, Patricia A. Totten, Carol A. Spiegel, Kirk C.S. Chen, David Eschenbach, King K. Holmes, Nonspecific vaginitis The American Journal of Medicine. ,vol. 74, pp. 14- 22 ,(1983) , 10.1016/0002-9343(83)91112-9
Attila T. Lorincz, Mark H. Schiffman, William J. Jaffurs, John Marlow, Allison P. Quinn, Gary F. Temple, Temporal associations of human papillomavirus infection with cervical cytologic abnormalities American Journal of Obstetrics and Gynecology. ,vol. 162, pp. 645- 651 ,(1990) , 10.1016/0002-9378(90)90974-C
Diane B. Ritter, Anna S. Kadish, Sten H. Vermund, Seymour L. Romney, Daniela Villari, Robert D. Burk, Detection of human papillomavirus deoxyribonucleic acid in exfoliated cervicovaginal cells as a predictor of cervical neoplasia in a high-risk population. American Journal of Obstetrics and Gynecology. ,vol. 159, pp. 1517- 1525 ,(1988) , 10.1016/0002-9378(88)90587-X
Julius Schachter, Chlamydia trachomatis and Cervical Neoplasia JAMA: The Journal of the American Medical Association. ,vol. 248, pp. 2134- 2138 ,(1982) , 10.1001/JAMA.1982.03330170038024
N Dyson, P. Howley, K Munger, E Harlow, The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product Science. ,vol. 243, pp. 934- 937 ,(1989) , 10.1126/SCIENCE.2537532