Legionella pneumophila Proliferation Is Not Dependent on Intracellular Replication

作者: Susanne Surman , Glyn Morton , Bill Keevil , Roy Fitzgeorge

DOI: 10.1128/9781555817985.CH17

关键词: BacteriaBiofilmVirulenceMicroorganismBiologyStrain (chemistry)Legionella pneumophilaProtozoaMicrobiologyIntracellular

摘要: The complexities of the relationship between Legionella pneumophila and other microorganisms for growth survival legionellae in environment is still not fully understood, though it generally believed that amoebae play an important role natural environment. Although strains varying virulence are isolated from environmental sources, accepted intracellular replication ability L. to proliferate model water system allowed development reproducible biofilms. A diverse but fairly constant consortium aquatic including fungi, bacteria, protozoa could be maintained this system. To investigate if have potential replicate without multiplication within a protozoal host, avirulent strain serogroup 1 Pontiac (Corby Strain) (CAC) was added If essential proliferation systems, then elimination trophozoites would prevent any further legionellae, consequently numbers decrease due dilution by continuous culture medium.

参考文章(12)
Susanne Barbara Surman, The integration of an avirulent Legionella pneumophila into aquatic biofilms University of Central Lancashire. ,(1994)
Sarah C. Tremaine, Aaron L. Mills, Inadequacy of the eucaryote inhibitor cycloheximide in studies of protozoan grazing on bacteria at the freshwater-sediment interface. Applied and Environmental Microbiology. ,vol. 53, pp. 1969- 1972 ,(1987) , 10.1128/AEM.53.8.1969-1972.1987
Nancy L Oleinick, None, Initiation and elongation of protein synthesis in growing cells: differential inhibition by cycloheximide and emetine. Archives of Biochemistry and Biophysics. ,vol. 182, pp. 171- 180 ,(1977) , 10.1016/0003-9861(77)90296-X
PETER SKALIY, Survival of the Legionnaires' Disease Bacterium in Water Annals of Internal Medicine. ,vol. 90, pp. 662- 663 ,(1979) , 10.7326/0003-4819-90-4-662
R. B. Fitzgeorge, A. Baskerville, M. Broster, P. Hambleton, P. J. Dennis, Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection Journal of Hygiene. ,vol. 90, pp. 81- 89 ,(1983) , 10.1017/S0022172400063877
R. I. Jepras, R. B. Fitzgeorge, A. Baskerville, A comparison of virulence of two strains of Legionella pneumophila based on experimental aerosol infection of guinea-pigs. Journal of Hygiene. ,vol. 95, pp. 29- 38 ,(1985) , 10.1017/S0022172400062252
T D Brock, Microbial growth rates in nature. Bacteriological Reviews. ,vol. 35, pp. 39- 58 ,(1971) , 10.1128/BR.35.1.39-58.1971