Neuroprotective effect of melatonin against lipopolysaccharide-induced depressive-like behavior in mice

摘要: Abstract Accumulating evidence indicates an interaction between inflammation and depression since increased levels of pro-inflammatory cytokines are associated with depression-related symptoms. Melatonin is a hormone synthesized secreted by the pineal gland antioxidant, anti-inflammatory antidepressant-like effects. In this way, it would be interesting to evaluate putative effect melatonin treatment in acute mice model depression. The present study aimed investigate on lipopolysaccharide (LPS) induced depressive-like behavior, neuroinflammation, oxidative stress alteration brain-derived neurotrophic fator (BDNF) levels. Mice were treated (10 mg/kg, i.p.) 30 min before LPS (0.5 mg/kg, injection. Twenty-four hours after infusion, submitted behavioral tests and, thereafter, biochemical determinations performed. prevented LPS-induced behavior forced swim tail suspension no alterations locomotor activity evaluated open field test. attenuated increase tumor necrosis factor-α (TNF-α) reduction BDNF hippocampus. Treatment also lipid peroxidation glutathione conclusion, suggests that exerted neuroprotective effects against which may related TNF-α release, modulation expression.