Tumor suppressor genes, proteins encoded thereby and use of said genes and proteins

摘要: The present invention is based on the pioneering finding that inhibition of expression certain genes counteracts cytokine-induced cell death. As long as these function normally, cytokine induces death; once said in inhibit, death inhibited. It follows therefrom normal In HeLa cells IFN-y a biphasic process, which comprises an initial cytostatic phase and subsequent cytotoxic (programmed death). novel discovered accordance with were found to affect only later, phase. These genes, referred 'DAP' (death-associated protein) include DNA molecules comprise coding sequence encoding products DAP or having similar biological activity, are at times collectively 'DAP molecules'. will be herein products'.