Adenosine in the Immune System
作者： György Haskó , Balázs Koscsó , Balázs Csóka
DOI: 10.1007/978-1-4614-3903-5_12
关键词: Extracellular 、 Immune system 、 Adenosine receptor 、 Caffeine 、 Cell surface receptor 、 Pharmacology 、 Purine 、 Nucleoside 、 Adenosine 、 Biology 、 Cell biology
摘要: Adenosine is an endogenous purine nucleoside, which produced during metabolic stress, including inflammatory insults and tissue injury, its extracellular level robustly increases in response to damage. Extracellular adenosine orchestrates immune/inflammatory responses by activating receptors on the surface of innate adaptive immune cells. The four receptors, A1, A2A, A2B, A3, are G protein-coupled membrane can be expressed every cell. This book chapter summarizes our knowledge about modulatory effect focusing effects various cell populations.
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