IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation.
作者： Jorge Lloberas , Jordi Xaus , Antonio Celada , Concepció Soler , Carme Lluis
DOI:
关键词: Cell biology 、 Endocrinology 、 Adenosine A1 receptor 、 Adenosine A3 receptor 、 Receptor 、 Internal medicine 、 Proinflammatory cytokine 、 Purinergic signalling 、 Stimulation 、 Biology 、 Adenosine receptor 、 Adenosine
摘要: Adenosine is a potent endogenous anti-inflammatory agent released by cells in metabolically unfavorable conditions, such as hypoxia or ischemia. modulates different functional activities macrophages. Some of these are believed to be induced through the uptake adenosine into macrophages, while others due interaction with specific cell surface receptors. In murine bone marrow-derived use radioligands for receptors suggests presence A 2B and 3 receptor subtypes. The was confirmed flow cytometry using Abs. indicated fact that agonists receptors, but not 1 , 2A lead an increase cAMP levels. IFN-γ up-regulates protein gene expression induction de novo synthesis. up-regulation correlates production macrophages treated agonist. stimulation its analogues inhibits IFN-γ-induced MHC class II genes also nitric oxide synthase proinflammatory cytokines. Therefore, could feedback mechanism macrophage deactivation.
pubpeer.com参考文章(51)
Michael Williams, Adenosine and Adenosine Receptors ,(1990)
M Baccarini, E R Stanley, D Buscher, A Bartocci, P Dello Sbarba, IFN-gamma/lipopolysaccharide activation of macrophages is associated with protein kinase C-dependent down-modulation of the colony-stimulating factor-1 receptor. Journal of Immunology. ,vol. 149, pp. 2656- 2661 ,(1992)
J Barankiewicz, H M Dosch, A Cohen, Extracellular nucleotide catabolism in human B and T lymphocytes. The source of adenosine production. Journal of Biological Chemistry. ,vol. 263, pp. 7094- 7098 ,(1988) , 10.1016/S0021-9258(18)68609-0
R H Fertel, D Mullet, D Kniss, G W Cox, An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-gamma-treated macrophages. Journal of Immunology. ,vol. 158, pp. 897- 904 ,(1997)
L B Ivashkiv, A Castro, E M Schmitt, Inhibition of transcription factor Stat1 activity in mononuclear cell cultures and T cells by the cyclic AMP signaling pathway. Journal of Immunology. ,vol. 157, pp. 1415- 1421 ,(1996)
Vladimir Kvetan, Zoltán H. Németh, Stephen McCarthy Pastores, Csaba Szabó, Csaba Szabó, E. Vízi, G. Haskó, Adenosine Receptor Agonists Differentially Regulate IL-10, TNF-α, and Nitric Oxide Production in RAW 264.7 Macrophages and in Endotoxemic Mice Journal of Immunology. ,vol. 157, pp. 4634- 4640 ,(1996)
A Marchant, P Stordeur, O Le Moine, M Goldman, L Schandené, D de Groote, J Devière, Adenosine enhances IL-10 secretion by human monocytes. Journal of Immunology. ,vol. 156, pp. 4408- 4414 ,(1996)
G Vairo, S Argyriou, A M Bordun, G Whitty, J A Hamilton, Inhibition of the signaling pathways for macrophage proliferation by cyclic AMP. Lack of effect on early responses to colony stimulating factor-1. Journal of Biological Chemistry. ,vol. 265, pp. 2692- 2701 ,(1990) , 10.1016/S0021-9258(19)39857-6
J Guardiola, C Perfetto, A Maffei, G Del Pozzo, N Ombra, Transcriptional and post-transcriptional regulation of human MHC class II genes require the synthesis of short-lived proteins. Journal of Immunology. ,vol. 142, pp. 3657- 3661 ,(1989)
L D McVittie, D R Sibley, L C Mahan, C R Gerfen, F J Monsma, H Nakata, E M Smyk-Randall, Cloning and expression of an A1 adenosine receptor from rat brain Molecular Pharmacology. ,vol. 40, pp. 1- 7 ,(1991)