Metabolism meets immunity: The role of free fatty acid receptors in the immune system
作者： Elisa Alvarez-Curto , Graeme Milligan
DOI: 10.1016/J.BCP.2016.03.017
关键词: adipocyte protein 2 、 G protein-coupled receptor 、 Immune system 、 Intestinal mucosa 、 Receptor 、 Nutrient sensing 、 Fatty acid 、 Intestinal epithelium 、 Biology 、 Biochemistry
摘要: There are significant numbers of nutrient sensing G protein-coupled receptors (GPCRs) that can be found in cells the immune system and tissues involved metabolic function, such as pancreas or intestinal epithelium. The family free fatty acid (FFAR1-4, GPR84), plus a few other metabolite (GPR109A, GPR91, GPR35) have been for this reason focus studies linking effects nutrients with immunological responses. A number beneficial anti-inflammatory credited to dietary fats omega-3 acids attributed their actions on FFAR4.This might play an important protective role development obesity, insulin resistance asthma. short-chain resulting from fermentation fibre by microbiota regulating acute inflammatory responses is also discussed. Finally we assess therapeutic potential treat pathologies where inflammation major factor type 2 diabetes, whether use novel synthetic molecules modulation individual's diet.
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Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z. Görgün, K. Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S. Hotamisligil, A central role for JNK in obesity and insulin resistance Nature. ,vol. 420, pp. 333- 336 ,(2002) , 10.1038/NATURE01137
Thomas M. Stulnig, Immunomodulation by polyunsaturated fatty acids: mechanisms and effects. International Archives of Allergy and Immunology. ,vol. 132, pp. 310- 321 ,(2003) , 10.1159/000074898
Shin'ichi Fukunaga, Shingo Setoguchi, Akira Hirasawa, Gozoh Tsujimoto, Monitoring ligand-mediated internalization of G protein-coupled receptor as a novel pharmacological approach. Life Sciences. ,vol. 80, pp. 17- 23 ,(2006) , 10.1016/J.LFS.2006.08.022
Celilia Hofmann, Kathryn Lorenz, SS Braithwaite, JR Colca, BJ Palazuk, GS Hotamisligil, BM Spiegelman, None, Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. ,vol. 134, pp. 264- 270 ,(1994) , 10.1210/ENDO.134.1.8275942
Mark K Nøhr, Maria H Pedersen, Andreas Gille, Kristoffer L Egerod, Maja S Engelstoft, Anna Sofie Husted, Rasmus M Sichlau, Kaare V Grunddal, Steen Seier Poulsen, Sangdon Han, Robert M Jones, Stefan Offermanns, Thue W Schwartz, None, GPR41/FFAR3 and GPR43/FFAR2 as Cosensors for Short-Chain Fatty Acids in Enteroendocrine Cells vs FFAR3 in Enteric Neurons and FFAR2 in Enteric Leukocytes Endocrinology. ,vol. 154, pp. 3552- 3564 ,(2013) , 10.1210/EN.2013-1142
Aurélien Trompette, Eva S Gollwitzer, Koshika Yadava, Anke K Sichelstiel, Norbert Sprenger, Catherine Ngom-Bru, Carine Blanchard, Tobias Junt, Laurent P Nicod, Nicola L Harris, Benjamin J Marsland, Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis Nature Medicine. ,vol. 20, pp. 159- 166 ,(2014) , 10.1038/NM.3444
Mikael Bjursell, Xiufeng Xu, Therése Admyre, Gerhard Böttcher, Sofia Lundin, Ralf Nilsson, Virginia M. Stone, Noel G. Morgan, Yan Y. Lam, Leonard H. Storlien, Daniel Lindén, David M. Smith, Mohammad Bohlooly-Y, Jan Oscarsson, The beneficial effects of n-3 polyunsaturated fatty acids on diet induced obesity and impaired glucose control do not require Gpr120. PLOS ONE. ,vol. 9, ,(2014) , 10.1371/JOURNAL.PONE.0114942
A. Salehi, E. Flodgren, N. E. Nilsson, J. Jimenez-Feltstrom, J. Miyazaki, C. Owman, B. Olde, Free fatty acid receptor 1 (FFA 1 R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion Cell and Tissue Research. ,vol. 322, pp. 207- 215 ,(2005) , 10.1007/S00441-005-0017-Z
H Chung, Y S Lee, R Mayoral, D Y Oh, J T Siu, N J Webster, D D Sears, J M Olefsky, L G Ellies, Omega-3 fatty acids reduce obesity-induced tumor progression independent of GPR120 in a mouse model of postmenopausal breast cancer Oncogene. ,vol. 34, pp. 3504- 3513 ,(2015) , 10.1038/ONC.2014.283
Jerry A. Nick, Natalie J. Avdi, Scott K. Young, Lisa A. Lehman, Patrick P. McDonald, S. Courtney Frasch, Marcella A. Billstrom, Peter M Henson, Gary L. Johnson, G. Scott Worthen, Selective activation and functional significance of p38α mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils Journal of Clinical Investigation. ,vol. 103, pp. 851- 858 ,(1999) , 10.1172/JCI5257