The abnormalities in the p53/p21WAF1 pathway have a significant role in the pathogenesis and progression of gastrointestinal stromal tumors.

摘要: To elucidate the prognostic role and relationship of p53/p21/PCNA pathway in gastrointestinal stromal tumors (GISTs), a total 167 resected gastric small intestinal CD117-positive tumor specimens were collected from January 1987 to December 2000. Immunohistochemical studies performed on paraffin sections with antibodies p53, p21/WAF1, proliferating cell nuclear antigen (PCNA) Ki-67. The immunoreactivity four markers was recorded by labeling index (LI, %) for clinicopathologic survival correlation. 0-83% 0-81% 0-33% Ki-67 12-92% PCNA. Completely negative immunostaining (LI or =5 cm, p=0.003), increased mitosis (> =5/50 HPF, p<0.001), high NIH risk (p<0.001), non-spindle type (p=0.024), p53 LI p21/WAF1 (p=0.007), (p<0.001) PCNA factors poor disease-free survival. Independent are size, risk, LI. We demonstrated first evidence linear tumors. Abnormalities p53/p21WAF1 lead states, thereby triggering progression GISTs.