Predictive value of p53 expression in the risk of malignant gastrointestinal stromal tumors: Evidence from 19 studies.
作者： LIANG ZONG , PING CHEN , JIAN JIANG , LEI WANG , QING GUO LI
DOI: 10.3892/ETM.2011.369
关键词: Pathology 、 Stromal cell 、 Odds ratio 、 Cancer 、 Confidence interval 、 Gastroenterology 、 Molecular medicine 、 Oncogene 、 Internal medicine 、 Text mining 、 GiST 、 Medicine
摘要: The current published data on p53 expression and its predictive value in the risk of malignant gastrointestinal stromal tumors (GIST) has are inconclusive. To derive a more precise estimation correlation between biological behavior GIST, meta-analysis was performed. Studies were identified by searching PubMed Embase. Inclusion criteria GIST patients, evaluation malignancy. odds ratio (OR) for positive rate benign group vs. that ORs National Institutes Health (NIH) very low + (VL+L) NIH intermediate high (I+H) calculated with 95% confidence interval (CI) each study as an p53. A total 19 studies including 1163 patients involved this meta-analysis. overall OR revealed significantly elevated risks achieved (OR 0.14, CI: 0.06–0.31, P<0.00001, Pheterogeneity=0.86). Moreover, I+H comparison VL+L (OR, 0.25; CI, 0.17–0.38; Pheterogeneity=0.04). results indicate correlates poor prognosis close relationship within group.
sci-hub.se 参考文章(38)
Sakari Knuutila, Wa’el El-Rifai, Maarit Sarlomo-Rikala, Leif C. Andersson, Markku Miettinen, DNA sequence copy number changes in gastrointestinal stromal tumors: tumor progression and prognostic significance. Cancer Research. ,vol. 60, pp. 3899- 3903 ,(2000)
Lopes, Silva, Seixas, Cirnes, Seruca, Microsatellite instability is not associated with degree of malignancy and p53 expression of gastrointestinal stromal tumours. Histopathology. ,vol. 33, pp. 579- 581 ,(1998) , 10.1046/J.1365-2559.1998.0525D.X
Shinji Sakurai, Masashi Fukayama, Yasuharu Kaizaki, Ken Saito, Kyotaro Kanazawa, Masatsugu Kitamura, Yoshiaki Iwasaki, Tsunekazu Hishima, Yukiko Hayashi, Morio Koike, Telomerase activity in gastrointestinal stromal tumors Cancer. ,vol. 83, pp. 2060- 2066 ,(1998) , 10.1002/(SICI)1097-0142(19981115)83:10<2060::AID-CNCR3>3.0.CO;2-#
Lisandro Ferreira Lopes, Elida B Ojopi, Carlos E Bacchi, None, Gastrointestinal stromal tumor in Brazil: clinicopathology, immunohistochemistry, and molecular genetics of 513 cases. Pathology International. ,vol. 58, pp. 344- 352 ,(2008) , 10.1111/J.1440-1827.2008.02235.X
R M Feakins, The expression of p53 and bcl-2 in gastrointestinal stromal tumours is associated with anatomical site, and p53 expression is associated with grade and clinical outcome Histopathology. ,vol. 46, pp. 270- 279 ,(2005) , 10.1111/J.1365-2559.2005.02071.X
Christopher D.M. Fletcher, Jules J. Berman, Christopher Corless, Fred Gorstein, Jerzy Lasota, B.Jack Longley, Markku Miettinen, Timothy J. O'Leary, Helen Remotti, Brian P. Rubin, Barry Shmookler, Leslie H. Sobin, Sharon W. Weiss, Diagnosis of gastrointestinal stromal tumors: A consensus approach Human Pathology. ,vol. 33, pp. 459- 465 ,(2002) , 10.1053/HUPA.2002.123545
D. C. Chhieng, R. S. Meara, J. Cangiarella, A. Simsir, D. Horton, I. Eltoum, Prediction of aggressiveness of gastrointestinal stromal tumours based on immunostaining with bcl-2, Ki-67 and p53. Cytopathology. ,vol. 18, pp. 283- 289 ,(2007) , 10.1111/J.1365-2303.2007.00505.X
Xiaojuan Wang, Ichiro Mori, Weihua Tang, Hirotoshi Utsunomiya, Misa Nakamura, Yasushi Nakamura, Genying Zhou, Kakudo Kennichi, Helpful parameter for malignant potential of gastrointestinal stromal tumors (GIST). Japanese Journal of Clinical Oncology. ,vol. 32, pp. 347- 351 ,(2002) , 10.1093/JJCO/HYF074
Muna Sabah, Robert Cummins, Mary Leader, Elaine Kay, Altered expression of cell cycle regulatory proteins in gastrointestinal stromal tumors: markers with potential prognostic implications. Human Pathology. ,vol. 37, pp. 648- 655 ,(2006) , 10.1016/J.HUMPATH.2006.01.023
Norimoto Nakamura, Hidetaka Yamamoto, Takashi Yao, Yoshinao Oda, Ken-ichi Nishiyama, Masakazu Imamura, Tomomi Yamada, Hajime Nawata, Masazumi Tsuneyoshi, Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade Human Pathology. ,vol. 36, pp. 828- 837 ,(2005) , 10.1016/J.HUMPATH.2005.03.012