Altered expression of cell cycle regulatory proteins in gastrointestinal stromal tumors: markers with potential prognostic implications.

摘要: Summary Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of digestive tract. The prediction malignant potential GISTs is still difficult. Altered cell cycle regulation may underlie tumorigenesis and/or progression human malignancies. Although p53 and Bcl-2 have been extensively investigated in GISTs, little known about frequency expression possible clinical implications alterations other regulatory proteins these neoplasms. We previously role loss p16 INK4A by heterozygosity immunohistochemistry found that 9p confined to GISTs. This has led us investigate tumors. Twenty-three cases GIST (9 low [LMP], 10 primary malignant, 4 intra-abdominal recurrences) were examined. All strongly positive for KIT (CD117). Immunohistochemical stains carried out on tissue microarrays evaluate involved G 1 -S transition regulate apoptosis including Rb, E2F1, cyclin D1, CDK4, CDK6, p27 KIP1 , p21 WAF1/CIP1 p53, Mdm2, Bcl-2, Bax. phenotypes identified as follows: 39.1%; 69.6%; 30.4%; 100%; 47.8%; 43.5%; 17.4%; 91.3%; Bax, 100%. Malignant more likely be associated with a E2F1 phenotype negative phenotype. It was concluded aberration regulators frequent finding contributing factor pathogenesis While some seen LMP therefore represent an early event molecular than utility complementary tools prognostication