BIM MEDIATES IMATINIB-INDUCED APOPTOSIS OF GASTROINTESTINAL STROMAL TUMORS: TRANSLATIONAL IMPLICATIONS

Helen E. Remotti, Frank Aldenborg, Jeanne M. Meis-Kindblom, Lars Gunnar Kindblom, Gastrointestinal pacemaker cell tumor (GIPACT): gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal. American Journal of Pathology. ,vol. 152, pp. 1259- 1269 ,(1998)

Shaun P. Holmgreen, Suzanne Cory, Elizabeth Baker, Leonie Gibson, Jerry M. Adams, Nancy A. Jenkins, Neal G. Copeland, Grant R. Sutherland, David C.S. Huang, Ora Bernard, bcl-w, a novel member of the bcl-2 family, promotes cell survival. Oncogene. ,vol. 13, pp. 665- 675 ,(1996)

Lynda Chin, Alice Tam, Jason Pomerantz, Michelle Wong, Jocelyn Holash, Nabeel Bardeesy, Qiong Shen, Ronan O'Hagan, Joe Pantginis, Hao Zhou, James W. Horner, Carlos Cordon-Cardo, George D. Yancopoulos, Ronald A. DePinho#, Essential role for oncogenic Ras in tumour maintenance Nature. ,vol. 400, pp. 468- 472 ,(1999) , 10.1038/22788

François Xavier Mahon, Michael W. N. Deininger, Beate Schultheis, Jérome Chabrol, Josy Reiffers, John M. Goldman, Junia V. Melo, Selection and characterization of BCR-ABL positive cell lines with differential sensitivity to the tyrosine kinase inhibitor STI571: diverse mechanisms of resistance Blood. ,vol. 96, pp. 1070- 1079 ,(2000) , 10.1182/BLOOD.V96.3.1070

Mami U, Toshiyuki Miyashita, Yoshiaki Shikama, Keiko Tadokoro, Masao Yamada, Molecular cloning and characterization of six novel isoforms of human Bim, a member of the proapoptotic Bcl-2 family1 FEBS Letters. ,vol. 509, pp. 135- 141 ,(2001) , 10.1016/S0014-5793(01)03145-3

David A Norris, Yiqun G Shellman, Deborah Ribble, Nathaniel B Goldstein, A simple technique for quantifying apoptosis in 96-well plates BMC Biotechnology. ,vol. 5, pp. 12- 12 ,(2005) , 10.1186/1472-6750-5-12

Dejka M. Steinert, Mauricio Oyarzo, Xuemei Wang, Haesun Choi, Peter F. Thall, L. Jeffrey Medeiros, A. Kevin Raymond, Robert S. Benjamin, Wei Zhang, Jonathan C. Trent, Expression of Bcl-2 in gastrointestinal stromal tumors : Correlation with progression-free survival in 81 patients treated with imatinib mesylate Cancer. ,vol. 106, pp. 1617- 1623 ,(2006) , 10.1002/CNCR.21781

Vincent, E. Sollars, Epigenetic modification as an enabling mechanism for leukemic transformation Frontiers in Bioscience. ,vol. 10, pp. 1635- ,(2005) , 10.2741/1647

Claudia S. Huettner, Pu Zhang, Richard A. Van Etten, Daniel G. Tenen, Reversibility of acute B-cell leukaemia induced by BCR-ABL1. Nature Genetics. ,vol. 24, pp. 57- 60 ,(2000) , 10.1038/71691

Michael E. O'Dwyer, Michael J. Mauro, Brian J. Druker, STI571 as a targeted therapy for CML. Cancer Investigation. ,vol. 21, pp. 429- 438 ,(2003) , 10.1081/CNV-120018235