PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
作者： Michael C Heinrich , Christopher L Corless , Anette Duensing , Laura McGreevey , Chang-Jie Chen
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摘要: Most gastrointestinal stromal tumors (GISTs) have activating mutations in the KIT receptor tyrosine kinase, and most patients with GISTs respond well to Gleevec, which inhibits kinase activity. Here we show that approximately 35% (14 of 40) lacking intragenic activation related platelet-derived growth factor alpha (PDGFRA). Tumors expressing or PDGFRA oncoproteins were indistinguishable respect downstream signaling intermediates cytogenetic changes associated tumor progression. Thus, appear be alternative mutually exclusive oncogenic mechanisms GISTs.
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