Genetic Markers in Sporadic Tumors

摘要: Progress in understanding the molecular basis of neoplastic transformation has strengthened concept that cancer is a genetic disease. This concept, however, lumps together two types diseases with same outcome: first linked to an entirely somatic cell-gene deregulation and second dealing susceptibility. At cell level, genes control careful balance between increase number withdrawal from cycle promotes growth by disrupting this balance. occurs as result circumvention apoptotic machinery, promotion division proliferation, loss differentiation pathways, disruption cell-cell communication interaction. Thus, represents end point multistep process involving stimulatory inhibitory signals provided controlled products genes.