p27kip1 Protein Expression Correlates With Survival in Myxoid and Round-Cell Liposarcoma
作者： Andre M. Oliveira , Antonio G. Nascimento , Scott H. Okuno , Ricardo V. Lloyd
DOI: 10.1200/JCO.2000.18.15.2888
关键词: Liposarcoma 、 Proportional hazards model 、 Pathology 、 Survival analysis 、 Antigen 、 P27Kip1 Protein 、 Medicine 、 Immunohistochemistry 、 Sarcoma 、 Round Cell Liposarcoma
摘要: PURPOSE: The p27kip1 protein (p27) is a cyclin-dependent kinase inhibitor that has been shown to be an independent prognostic factor in variety of human neoplasms. Low expression p27 tends occur more aggressive role as the spectrum myxoid and round-cell liposarcomas not examined. MATERIALS AND METHODS: Forty-seven cases were Clinicopathologic features immunohistochemical Ki-67 antigen studied all cases. Survival analysis was performed using log-rank test Cox multivariate regression model. RESULTS: male:female ratio 1.4:1, mean age at diagnosis 45 years. tumors located lower extremities (94%) retroperitoneum (6%). median tumor size 13.5 cm. follow-up 6.3 years, overall 5- 10-year survival rates 76% 67%, respectively. identifie...
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