Neonatal Predictors of Infection Status and Early Death Among 332 Infants at Risk of HIV-1 Infection Monitored Prospectively From Birth

摘要: Background and Methods. Differences in newborn outcome measures for human immunodeficiency virus (HIV)-1-infected HIV-1-exposed but uninfected infants have been found several studies, not others. Eighty-four infected 248 children born to HIV-1-seropositive mothers followed prospectively a multicenter, perinatal HIV-1 transmission cohort study were compared differences maternal demographics, health status, measures, including delivery complications, physical examination findings, neonatal laboratory results. Results. Mothers of HIV-1-infected more likely than those acquired syndrome (AIDS) diagnosed through 2 weeks postpartum (21% vs 11%, P =.04) ; the rate 38 women with AIDS was 37% 22% 245 without AIDS. Two 27 (7%) receiving zidovudine during pregnancy had 73 (27%) 275 who did receive (P = .033). Mean gestational age significantly lower among (37 weeks) (38 <.001). Infected higher rates prematurity (gestational less 37 (33% 19%, =.01) extreme 34 (18% 6%, =.001) infants. Infection associated birth weight (2533 g 2862 g, <.001) smaller head circumference (32.0 cm 33.1 cm, .001). be small (26% 16%, .04) low (less 2500 g) (45% 29%, =.006) uninfected. Twenty-two (26%) died median follow-up 27.6 months (range 1.9 98.3 months). Prematurity predictive survival : by Kaplan-Meier, an estimated 55% (95% confidence interval, 31% 72%) preterm survived 24 84% 70% 92%) full-term =.005). Conclusion. Infants are at risk infection yet diagnosed. Women appear transmit their Significantly intrauterine growth retardation uninfected, control group. shortened Measures gestation important predictors status seropositive prognosis infant. Pediatrics 1995 ;96 :451-458 infection, pediatric HIV-1, prematurity.