Cell competition: Dying for communal interest

作者: Maximilien Courgeon , Nikolaos Konstantinides , Claude Desplan

DOI: 10.1016/J.CUB.2015.02.047

关键词: Competition (biology)CellBiologyCell biologyBioinformaticsRegeneration (biology)Mechanism (biology)

摘要: Viable but slower growing cells are eliminated during embryonic development through the process of cell competition. Two new studies highlight a role for competition adulthood as surveillance mechanism that ensures tissue integrity homeostasis, regeneration, and aging.

参考文章(17)
Marisa M. Merino, Christa Rhiner, Marta Portela, Eduardo Moreno, “Fitness Fingerprints” Mediate Physiological Culling of Unwanted Neurons in Drosophila Current Biology. ,vol. 23, pp. 1300- 1309 ,(2013) , 10.1016/J.CUB.2013.05.053
Chi-Kuang Yao, Yong Qi Lin, Cindy V. Ly, Tomoko Ohyama, Claire M. Haueter, Vera Y. Moiseenkova-Bell, Theodore G. Wensel, Hugo J. Bellen, A Synaptic Vesicle-Associated Ca2+ Channel Promotes Endocytosis and Couples Exocytosis to Endocytosis Cell. ,vol. 138, pp. 947- 960 ,(2009) , 10.1016/J.CELL.2009.06.033
Bangfu Zhu, Jenny A Pennack, Peter McQuilton, Manuel G Forero, Kenji Mizuguchi, Ben Sutcliffe, Chun-Jing Gu, Janine C Fenton, Alicia Hidalgo, None, Drosophila Neurotrophins Reveal a Common Mechanism for Nervous System Formation PLoS Biology. ,vol. 6, pp. e284- 2495 ,(2008) , 10.1371/JOURNAL.PBIO.0060284
Ginés Morata, Pedro Ripoll, Minutes: Mutants of Drosophila autonomously affecting cell division rate Developmental Biology. ,vol. 42, pp. 211- 221 ,(1975) , 10.1016/0012-1606(75)90330-9
Marisa M. Merino, Christa Rhiner, Jesus M. Lopez-Gay, David Buechel, Barbara Hauert, Eduardo Moreno, Elimination of unfit cells maintains tissue health and prolongs lifespan. Cell. ,vol. 160, pp. 461- 476 ,(2015) , 10.1016/J.CELL.2014.12.017
Eduardo Moreno, Yuniel Fernandez-Marrero, Patricia Meyer, Christa Rhiner, Brain Regeneration in Drosophila Involves Comparison of Neuronal Fitness Current Biology. ,vol. 25, pp. 955- 963 ,(2015) , 10.1016/J.CUB.2015.02.014
Marta Portela, Sergio Casas-Tinto, Christa Rhiner, Jesús M. López-Gay, Orlando Domínguez, Davide Soldini, Eduardo Moreno, Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition Developmental Cell. ,vol. 19, pp. 562- 573 ,(2010) , 10.1016/J.DEVCEL.2010.09.004
S. N. Meyer, M. Amoyel, C. Bergantiños, C. de la Cova, C. Schertel, K. Basler, L. A. Johnston, An ancient defense system eliminates unfit cells from developing tissues during cell competition Science. ,vol. 346, pp. 1258236- 1258236 ,(2014) , 10.1126/SCIENCE.1258236
Eduardo Moreno, Konrad Basler, dMyc Transforms Cells into Super-Competitors Cell. ,vol. 117, pp. 117- 129 ,(2004) , 10.1016/S0092-8674(04)00262-4
Eduardo Moreno, Konrad Basler, Ginés Morata, Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing development Nature. ,vol. 416, pp. 755- 759 ,(2002) , 10.1038/416755A