Drosophila SPARC Is a Self-Protective Signal Expressed by Loser Cells during Cell Competition
作者： Marta Portela , Sergio Casas-Tinto , Christa Rhiner , Jesús M. López-Gay , Orlando Domínguez
DOI: 10.1016/J.DEVCEL.2010.09.004
关键词:
摘要: During development and aging, animals suffer insults that modify the fitness of individual cells. In Drosophila, elimination viable but suboptimal cells is mediated by cell competition, ensuring that these do not accumulate during development. addition, certain genes such as Drosophila homolog human c-myc (dmyc) are able to transform into supercompetitors, which eliminate neighboring wild-type apoptosis overproliferate, leaving total numbers unchanged. Here we have identified Sparc an early marker transcriptionally upregulated in loser provides a transient protection inhibiting Caspase activation outcompeted Overall, describe unexpected existence physiological mechanism counteracts competition
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