Cancer gene therapy with T cell receptors and chimeric antigen receptors
作者： Hans J Stauss , Emma C Morris , Hinrich Abken
DOI: 10.1016/J.COPH.2015.08.006
关键词: Medicine 、 Antigen 、 T-cell receptor 、 Cancer research 、 Chimeric antigen receptor 、 B cell 、 Cytotoxic T cell 、 Streptamer 、 Antigen-presenting cell 、 Immunology 、 Major histocompatibility complex
摘要: Viral and non-viral gene transfer technologies have been used to efficiently generate therapeutic T cells with desired cancer-specificity. Chimeric antigen receptors (CARs) redirect cell specificity toward antibody-recognized antigens expressed on the surface of cancer cells, while (TCRs) extend range targets include intracellular tumor antigens. CAR redirected specific for B differentiation CD19 shown dramatic efficacy in treatment malignancies, TCR-redirected benefits patients suffering from solid cancer. In this review we will present strategies optimize TCR function, discuss importance target selection enhance specificity, reducing on-target off-target toxicity.
elsevier.com
sci-hub.se 参考文章(53)
Daniel Sommermeyer, Wolfgang Uckert, Minimal Amino Acid Exchange in Human TCR Constant Regions Fosters Improved Function of TCR Gene-Modified T Cells The Journal of Immunology. ,vol. 184, pp. 6223- 6231 ,(2010) , 10.4049/JIMMUNOL.0902055
Thomas Stanislawski, Ralf-Holger Voss, Carina Lotz, Elena Sadovnikova, Ralph A. Willemsen, Jürgen Kuball, Thomas Ruppert, Reinder L. H. Bolhuis, Cornelius J. Melief, Christoph Huber, Hans J. Stauss, Matthias Theobald, Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer. Nature Immunology. ,vol. 2, pp. 962- 970 ,(2001) , 10.1038/NI1001-962
Andreas A. Hombach, Verena Schildgen, Claudia Heuser, Ricarda Finnern, David E. Gilham, Hinrich Abken, T Cell Activation by Antibody-Like Immunoreceptors: The Position of the Binding Epitope within the Target Molecule Determines the Efficiency of Activation of Redirected T Cells Journal of Immunology. ,vol. 178, pp. 4650- 4657 ,(2007) , 10.4049/JIMMUNOL.178.7.4650
A. D. G. Lawson, H. M. Finney, C. R. Bebbington, A. N. C. Weir, Chimeric Receptors Providing Both Primary and Costimulatory Signaling in T Cells from a Single Gene Product Journal of Immunology. ,vol. 161, pp. 2791- 2797 ,(1998)
Andreas Hombach, Anja Wieczarkowiecz, Thomas Marquardt, Claudia Heuser, Loretta Usai, Christoph Pohl, Barbara Seliger, Hinrich Abken, Tumor-Specific T Cell Activation by Recombinant Immunoreceptors: CD3ζ Signaling and CD28 Costimulation Are Simultaneously Required for Efficient IL-2 Secretion and Can Be Integrated Into One Combined CD28/CD3ζ Signaling Receptor Molecule The Journal of Immunology. ,vol. 167, pp. 6123- 6131 ,(2001) , 10.4049/JIMMUNOL.167.11.6123
Katja Simon-Keller, Annette Paschen, Andreas A. Hombach, Philipp Ströbel, Jean-Michel Coindre, Stefan B. Eichmüller, Angela Vincent, Stefan Gattenlöhner, Florian Hoppe, Ivo Leuschner, Sabine Stegmaier, Ewa Koscielniak, Martin Leverkus, Dario C. Altieri, Hinrich Abken, Alexander Marx, Survivin blockade sensitizes rhabdomyosarcoma cells for lysis by fetal acetylcholine receptor-redirected T cells American Journal of Pathology. ,vol. 182, pp. 2121- 2131 ,(2013) , 10.1016/J.AJPATH.2013.02.017
Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, Richard G. Carroll, Gwendolyn K. Binder, David Teachey, Minu Samanta, Mehdi Lakhal, Brian Gloss, Gwenn Danet-Desnoyers, Dario Campana, James L. Riley, Stephan A. Grupp, Carl H. June, Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo Molecular Therapy. ,vol. 17, pp. 1453- 1464 ,(2009) , 10.1038/MT.2009.83
Jennifer D Stone, Daniel T Harris, David M Kranz, TCR affinity for p/MHC formed by tumor antigens that are self-proteins: impact on efficacy and toxicity Current Opinion in Immunology. ,vol. 33, pp. 16- 22 ,(2015) , 10.1016/J.COI.2015.01.003
Andreas A. Hombach, Markus Chmielewski, Gunter Rappl, Hinrich Abken, Adoptive Immunotherapy with Redirected T Cells Produces CCR7− Cells That Are Trapped in the Periphery and Benefit from Combined CD28-OX40 Costimulation Human Gene Therapy. ,vol. 24, pp. 259- 269 ,(2013) , 10.1089/HUM.2012.247
David A. Williams, Adrian J. Thrasher, Concise Review: Lessons Learned From Clinical Trials of Gene Therapy in Monogenic Immunodeficiency Diseases Stem Cells Translational Medicine. ,vol. 3, pp. 636- 642 ,(2014) , 10.5966/SCTM.2013-0206