Novel lβ-methylcarbapenems having cyclic sulfonamide moieties: Synthesis and evaluation of in vitro antibacterial activity
作者： Seong Jong Kim , Hyeong Beom Park , Jae Seoung Lee , Nam Hyun Jo , Kyung Ho Yoo
DOI: 10.1016/J.EJMECH.2007.02.001
关键词: Substituent 、 Antibacterial activity 、 Antibacterial agent 、 Lactam 、 Sulfonamide 、 Chemistry 、 Pyrrolidine 、 Chemical synthesis 、 Moiety 、 Stereochemistry 、 Combinatorial chemistry
摘要: Abstract The synthesis of a new series 1β-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested the effect substituent on pyrrolidine ring was investigated. A particular compound (IIIi) 2-methyl-[1,2,6]thiadiazinan-1,1-dioxide moiety showed most potent activity.
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