A novel carbapenem antibiotic, SM-7338 structure-activity relationships.
作者： MAKOTO SUNAGAWA , HARUKI MATSUMURA , TAKAAKI INOUE , MASATOMO FUKASAWA , MASUHIRO KATO
DOI: 10.7164/ANTIBIOTICS.43.519
关键词:
摘要: A series of new carbapenem compounds, which have a pyrrolidin-3'-ylthio group substituted with various aminocarbonyl at C-5' position as C-2 side chain, been prepared. The antibacterial activity and the stability to renal dehydropeptidase-I these compounds were investigated, structure-activity relationships discussed. In this series, SM-7338; (1R, 5S, 61S)-2-[(3S, 5S)-5-dimethylaminocarbonylpyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methylcarbapen-2-em-3-carboxylic acid (5a) was most interesting compound.
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