In Vitro and In Vivo Antibacterial Activities of S-4661, a New Carbapenem

摘要: The in vitro and vivo antibacterial activities of S-4661, a new 1beta-methylcarbapenem, were compared with those imipenem, meropenem, biapenem, cefpirome, ceftazidime. activity S-4661 against methicillin-susceptible staphylococci streptococci was comparable to that an MIC at which 90% the strains tested inhibited (MIC90) equal 0.5 microg/ml or less. highly active members family Enterobacteriaceae, Haemophilus influenzae, Moraxella catarrhalis, MIC90s ranging from 0.032 microg/ml. Against imipenem-resistant Pseudomonas aeruginosa, most among test agents (MIC90, 8 microg/ml). Furthermore, displayed high degree many ceftazidime-, ciprofloxacin-, gentamicin-resistant isolates P. aeruginosa. efficacy experimentally induced infections mice caused by gram-positive gram-negative bacteria, including penicillin-resistant Streptococcus pneumoniae drug-resistant reflected its potent levels plasma mice. We conclude is promising carbapenem for treatment -negative S.