Histamine derivatives and methods for their use as immunomodulators

作者: Kenneth L Melmon , Julia L Greenstein , Parisa Khosropour

DOI:

关键词: Antibody responseProliferative responseBiochemistryAntigen specificBinding selectivityImmune systemT cellHistamineHistamine receptorBiology

摘要: The present invention provides histamine derivatives and methods for using as immunomodulators in immunotherapeutics. More specifically, the inhibiting at least a portion of an antigen specific antibody response and/or T cell proliferative by immune system mammal comprising administering to said effective amount composition one derivative having binding specificity receptor.

参考文章(5)
Manzoor M. Khan, Kenneth L. Melmon, Michael Verlander, Murray Goodman, Debra Marr-Leisy, Histamine derivatives as immune modulators ,(1987)
Rong Qiu, M. M. Khan, K. L. Melmon, Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes. Journal of Pharmacology and Experimental Therapeutics. ,vol. 253, pp. 1245- 1252 ,(1990)
Kenneth L. Melmon, Manzoor M. Khan, Histamine and its lymphocyte-selective derivatives as immune modulators Trends in Pharmacological Sciences. ,vol. 8, pp. 437- 441 ,(1987) , 10.1016/0165-6147(87)90232-X
M. M. Khan, K. L. Melmon, D. Marr-Leisy, M. S. Verlander, M. Egli, S. Lok, M. Goodman, Congener derivatives and conjugates of histamine: synthesis and tissue and receptor selectivity of the derivatives. Journal of Medicinal Chemistry. ,vol. 30, pp. 2115- 2120 ,(1987) , 10.1021/JM00394A031