Flexible and robust patterning by centralized gene networks

摘要: We consider networks with two types of nodes. The v-nodes, called centers, are hyperconnected and interact one to another via many u-nodes, satellites. This centralized architecture, widespread in gene networks, realize a bow-tie scheme possesses interesting properties. Namely, this organization creates feedback loops that capable generate any prescribed patterning dynamics, chaotic or periodic, create number equilibrium states. show activation silencing node can sharply switch the network attractor, even if activated silenced is weakly connected. distinguish between dynamically different situations, "power center" (PC) when satellite response fast "satellite power" (SP) center fast. Using simple example we more robust respect time dependent perturbations, PC relative SP case. In theoretical molecular biology, class models be used reveal non-trivial relation architecture protein-DNA protein-protein interaction controllability space-time dynamics cellular processes.