Metabolic stability and epigenesis in randomly constructed genetic nets

作者: S.A. Kauffman

DOI: 10.1016/0022-5193(69)90015-0

关键词:

摘要: Proto-organisms probably were randomly aggregated nets of chemical reactions. The hypothesis that contemporary organisms are also randomly constructed molecular automata is examined by modeling the gene as a binary (on-off) device and studying the behavior of large, randomly constructed nets of these binary “genes”. The results suggest that, if each “gene” is directly affected by two or three other “genes”, then such random nets: behave with great order and stability; undergo behavior cycles whose length predicts cell replication time …

参考文章(18)
Brian Goodwin, Temporal organization in cells ,(1963)
C. H. Waddington, Cybernetics and Development Journal of the Operational Research Society. ,vol. 17, pp. 481- 482 ,(1966) , 10.1057/JORS.1966.85
R. F. Rosenberger, M. Kessel, Synchrony of Nuclear Replication in Individual Hyphae of Aspergillus nidulans Journal of Bacteriology. ,vol. 94, pp. 1464- 1469 ,(1967) , 10.1128/JB.94.5.1464-1469.1967
James Frederick Bonner, The molecular biology of development Oxford University Press. ,(1965)
MARTIN MACKLIN, Biological phase relationships. Nature. ,vol. 217, pp. 622- 624 ,(1968) , 10.1038/217622A0
Charles Walter, Rodger Parker, Martynas Yčas, A model for binary logic in biochemical systems Journal of Theoretical Biology. ,vol. 15, pp. 208- 217 ,(1967) , 10.1016/0022-5193(67)90201-9
MARK S. BRETSCHER, How repressor molecules function. Nature. ,vol. 217, pp. 509- 511 ,(1968) , 10.1038/217509A0