Method and device for determination of tissue specificity of free floating dna in bodily fluids

作者: Andrzej Sledziewski , Kurt Berlin

DOI:

关键词: Nucleic acidCellMethylationAnimal bodyDna concentrationBiologyDNAProliferative diseaseBiochemistryTissue specificity

摘要: The present invention relates to methods for detecting free floating nucleic acids, as in not cellular bound acids bodily fluids like plasma or serum fractions of human animal blood any other tissue samples derived from the body order diagnose a cell proliferative disease. Specifically detection increased levels fluids. Furthermore allows determine source enriched DNA by measuring ratio originating certain organ versus total organs given fluid sample specifying DNA's methylation pattern. This can be done with without increasing concentration biological sample. In preferred embodiment further analysis this pattern presence tumourous otherwise disease said organ.

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