Structural Basis of TLR5-Flagellin Recognition and Signaling

作者: S.-i. Yoon , O. Kurnasov , V. Natarajan , M. Hong , A. V. Gudkov

DOI: 10.1126/SCIENCE.1215584

关键词: TLR5Cell biologySignal transductionMutagenesisTranscription factorProtein structureBiologyVariable lymphocyte receptorFlagellinImmunologyTwo-hybrid screening

摘要: … implications of TLR5-flagellin recognition, we determined the crystal structure of zebrafish TLR5 (… with the D1/D2/D3 fragment of Salmonella flagellin, FliC, at 2.47 angstrom resolution. …

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