All You Need Is Light: Antimicrobial Photoinactivation as an Evolving and Emerging Discovery Strategy Against Infectious Disease

摘要: The story of prevention and control infectious diseases remains open a series highly virulent pathogens are emerging both in beyond the hospital setting. Antibiotics were an absolute success for previous era. academic industrial biomedical communities have now come together to formulate consensus beliefs regarding pursuit novel effective alternative anti-infective countermeasures. Photodynamic therapy was established successful modality malignancies but photodynamic inactivation has been transformed recently antimicrobial discovery development platform. concept is quite straightforward requires microbial exposure visible light energy, typically wavelengths region, that causes excitation photosensitizer molecules (either exogenous or endogenous), which results production singlet oxygen other reactive species react with intracellular components, consequently produce cell inactivation. It area increasing interest, as research advancing i) identify photochemical photophysical mechanisms involved inactivation; ii) develop potent clinically compatible photosensitizer; iii) understand how photoinactivation affected by key phenotypic elements (multidrug resistance efflux, virulence pathogenesis determinants, biofilms); iv) explore delivery platforms inspired current trends pharmacology nanotechnology; v) applications clinical setting such environmental disinfectants.