The Effects of Cyclosporin a on the Urine Excretion of Specific Proteins in Humans

摘要: Cyclosporin A (CyA) is widely used as an immunosuppressant following organ transplantation and in the treatment of various autoimmune disorders. major disadvantage its nephrotoxicity which probably multifactorial origin, involving acute, reversible haemodynamic changes irreversible tubulointerstitial injury focal glomerulosclerosis (Cohen et al, 1984; Klintmalm Myers Palestine 1986). There no satisfactory animal model for CyA assessment treated renal transplant recipients complicated by coexistence other For these reasons, we have chosen to study a group patients being with long-term disorder, primary biliary cirrhosis (PBC).