Localization of Tamm-Horsfall glycoprotein in the human kidney using immuno-fluorescence and immuno-electron microscopical techniques.

摘要: Small pieces of tissue obtained from apparently normal areas four surgically removed adult human kidneys were used in the present study. The results by immuno-fluorescence and immuno-electron microscopical techniques show that Tamm-Horsfall glycoprotein (THP) is thick ascending limbs loops Henle distal convoluted tubules. Within cells concerned, protein associated with luminal, lateral as well basal, plasma membranes their infoldings. macula densa are completely negative those proximal tubules, glomeruli collecting ducts. possible significance these findings relation to process urine dilution nephron discussed.