Metagenomics and antibiotics

作者: L. Garmendia , A. Hernandez , M.B. Sanchez , J.L. Martinez

DOI: 10.1111/J.1469-0691.2012.03868.X

关键词: Antibiotic resistance genesMobilomeComputational biologyAntimicrobialDrug resistanceResistomeAntibiotic resistanceMetagenomicsBiologyEcologyAntibiotics

摘要: Most of the bacterial species that form part biosphere have never been cultivated. In this situation, a comprehensive study communities requires utilization non-culture-based methods, which named metagenomics. paper we review use different metagenomic techniques for understanding effect antibiotics on microbial communities, to synthesize new antimicrobial compounds and analyse distribution antibiotic resistance genes in ecosystems. These include functional metagenomics, serves find or genes, descriptive changes composition microbiota track presence abundance already known

参考文章(24)
Selman A. Waksman, H. Boyd Woodruff, The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria*1 Journal of Bacteriology. ,vol. 40, pp. 581- 600 ,(1940) , 10.1128/JB.40.4.581-600.1940
Fernando Baquero, José-Luis Martínez, Rafael Cantón, Antibiotics and antibiotic resistance in water environments Current Opinion in Biotechnology. ,vol. 19, pp. 260- 265 ,(2008) , 10.1016/J.COPBIO.2008.05.006
Jose Luis Martinez, Alicia Fajardo, Leonor Garmendia, Alvaro Hernandez, Juan Francisco Linares, Laura Martínez-Solano, María Blanca Sánchez, A global view of antibiotic resistance Fems Microbiology Reviews. ,vol. 33, pp. 44- 65 ,(2009) , 10.1111/J.1574-6976.2008.00142.X
José L Martínez, Fernando Baquero, Dan I Andersson, None, Predicting antibiotic resistance Nature Reviews Microbiology. ,vol. 5, pp. 958- 965 ,(2007) , 10.1038/NRMICRO1796
Jose Luis Martinez, Environmental pollution by antibiotics and by antibiotic resistance determinants Environmental Pollution. ,vol. 157, pp. 2893- 2902 ,(2009) , 10.1016/J.ENVPOL.2009.05.051
Laurent Poirel, Jose-Manuel Rodriguez-Martinez, Hedi Mammeri, Alain Liard, Patrice Nordmann, Origin of Plasmid-Mediated Quinolone Resistance Determinant QnrA Antimicrobial Agents and Chemotherapy. ,vol. 49, pp. 3523- 3525 ,(2005) , 10.1128/AAC.49.8.3523-3525.2005
M. O. A. Sommer, G. Dantas, G. M. Church, Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora Science. ,vol. 325, pp. 1128- 1131 ,(2009) , 10.1126/SCIENCE.1176950
F. Baquero, C. Alvarez-Ortega, J. L. Martinez, Ecology and evolution of antibiotic resistance. Environmental Microbiology Reports. ,vol. 1, pp. 469- 476 ,(2009) , 10.1111/J.1758-2229.2009.00053.X