Update on genetic and clinical aspects of primary hyperparathyroidism

摘要: Primary hyperparathyroidism (pHPT) is a common endocrine disorder that predominantly affects postmenopausal women. It mostly caused by solitary tumours within the parathyroid glands. Although pathophysiology of pHPT still incompletely understood, recent studies provide new clues on development and cellular growth parathyroids associated with hypersecretion hormone hypercalcaemia. The natural course rather benign. Nowadays, it has become an oligo- or asymptomatic disease often only detected routine blood tests. These facts raise question whether to perform parathyroidectomy patients possible monitor these without surgery. aim this article review literature as regards (i) pathophysiological mechanisms underlie neoplasia (ii) defective calcium-sensing in (iii) environmental and/or genetic risk factors predispose promote neoplasia, well (iv) alternative approaches treat medically.